Zinc is responsible for Multiple aspects of the immune system, Skin to gene regulation within lymphocytes. Zinc is very much necessary for normal of cell development and functions. Responsible for nonspecific immunity. The importance of zinc for humans was recognized 40 years ago Severe immune dysfunctions were observed in Zinc-deficient patients. ZINC AND IMMUNITY The immune system is very much Zinc dependant and is very essential for normal functions and development of cell mediating innate immunity. zinc deficiency affects Macrophages.Phagocytosis, intracellular killing, and cytokine production.Zinc deficiency adversely affects the growth and function of T and B cells. The ability of zinc to function as an anti-oxidant and stabilize membranes suggests that it has a role in the prevention of free radical-induced injury during inflammatory processes. Various physiological activities in the body such as cell growth, cell differentiation and development are dependent on Zinc. Zinc plays a vital role in Catalytic activity of various enzymes in both plants and animals . Zinc plays important role in boosting the immune system. Zinc deficiency affects human health and responsible for many diseases such as hypogonadism, cognitive impairment, poor immune system, diarrhea, delayed wound healing, oligospermia, neurosensory disorders, decreased body mass. T helper cells are mainly Zinc dependent.